Younger age at diagnosis predisposes to mucosal recovery in celiac disease on a gluten-free diet
Villous atrophy can result in malabsorption leading to nutrient-deficiencies, one of the complications of celiac disease. Mitigation of villous atrophy associated with celiac disease include adherence to a gluten free diet (GFD) upon diagnosis which lead to mucosal recovery.
Szakacs et al (2017) performed a meta-analysis examining the effect of earlier celiac disease diagnosis on mucosal recovery. The meta-analysis included data from published papers discussing celiac patients, follow-up biopsy, and mucosal recovery with a gluten-free diet. Based on data pooled from 37 observational studies, more children showed higher complete recovery (65%) and disappearance of villous atrophy (74%) as compared to adults (24% and 58%, respectively), thus earlier celiac disease diagnosis may lead to improved recovery. Additionally, each year delay in the diagnosis results in an extra 1.106 odds ratio of having persisting duodenal abnormalities (2.751 odds ratio for 10 years).
The gluten free diet was examined as a factor for mucosal recovery. Following a 12- month gluten free diet, 38% of patients exhibited complete mucosal recovery, and 54% showed a disappearance of villous atrophy. Based on the observed studies, a year of diet may not be sufficient to achieve mucosal recovery and biopsies should be performed later in time.
Taken together, earlier diagnosis with early initiation of the diet can lead to higher mucosal recovery ratios, and may potentially reduce adverse events associated with celiac disease in the long term.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187526
The gluten free diet was examined as a factor for mucosal recovery. Following a 12- month gluten free diet, 38% of patients exhibited complete mucosal recovery, and 54% showed a disappearance of villous atrophy. Based on the observed studies, a year of diet may not be sufficient to achieve mucosal recovery and biopsies should be performed later in time.
Taken together, earlier diagnosis with early initiation of the diet can lead to higher mucosal recovery ratios, and may potentially reduce adverse events associated with celiac disease in the long term.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187526
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